PUBH 7015 Introduction to Clinical Epidemiology

Credit Points 10

Legacy Code 401173

Coordinator Felix Ogbo Opens in new window

Description This unit aims to impart the principles of population based (epidemiologic) evidence to the understanding of variations in the outcome of illness and the reasons thereof (Clinical Epidemiology) thereby providing the framework for finding the best answers to "real world" questions about clinical practice and health care. Individuals taking this course (who usually have a health care background) acquire the basic skills required to understand the fundamental questions about the effectiveness of clinical therapies, usefulness of screening and diagnostic tools, prognosis and disease causation and gain the skills required of effective Evidence-Based Medicine practitioners.

School Medicine

Student Contribution Band HECS Band 2 10cp

Check your HECS Band contribution amount via the Fees page.

Level Postgraduate Coursework Level 7 subject

Equivalent Subjects PUBH 7016 - Introduction to Epidemiology

Restrictions Students must be enrolled in a postgraduate program.

Assumed Knowledge

A background in health care is desirable.

Learning Outcomes

On successful completion of this subject, students should be able to:
  1. Generate a critical question leading up from a health scenario
  2. Locate, navigate and extract relevant data from important sources of health information
  3. Examine critically, synthesise and evaluate the basic principles underlying validity of the results of health care outcome studies
  4. Evaluate quantitatively the usefulness of diagnostic and screening tests in health care practice
  5. Examine critically, synthesise and evaluate point estimates (effect sizes) used in clinical epidemiology
  6. Examine critically, and evaluate principles underlying precision of the effect sizes reported in health care research
  7. Understand and apply the principles underlying the translation of research results to health care practice
  8. Integrate and apply results (generalise) to specific health care problems

Subject Content

1. Introduction and critical questioning: Knowledge gaps during the course of practice and asking foreground questions to fill these gaps, and focused questions that lead to effective search and appraisal strategies. This would involve development of critical questioning, identifying the specific patient population (P), the type of intervention in question (I), a comparison/control condition (C), and the outcomes for the patient population (O), or PICO. The different study designs used to answer critical questions descriptive, observational and experimental designs and their strengths and weaknesses.
2. Acquiring the information: The use of citation and synthesised (evidence based) library databases.
3. Are the results valid? - Sources of error in evidence such as random error, systematic error (bias) and confounding. Minimizing sources of error that decrease validity in clinical trial design eg allocation concealment, randomisation, blinding, matching, and loss to follow up. Effect modification and causality.
4. Quantitative aspects of diagnosis/screening:. Sensitivity, specificity, PPV, NPV and likelihood ratios. Introduction to ROC methods.
5. Effect size: Point estimates (measures of association, effect sizes) used in clinical epidemiology such as ratios, proportions, rates, OR, RR.
6. How precise were the study estimates?: Use of descriptive (data types, measures of central tendency and dispersion, normal distribution) and inferential statistics (hypothesis testing) in clinical research studies including P-values and confidence intervals.
7. Are the valid results

Assessment

The following table summarises the standard assessment tasks for this subject. Please note this is a guide only. Assessment tasks are regularly updated, where there is a difference your Learning Guide takes precedence.

Item Length Percent Threshold Individual/Group Task
Essay < 3000 words 60 N Individual
Short answer questions Throughout semester 40 N Individual

Prescribed Texts

  • Doi SA. Understanding Evidence in Health Care: Using Clinical Epidemiology; ISBN: 9781420256697; Publisher: Palgrave Macmillan; Edition: 1st edition, 2012

Teaching Periods

2022 Semester 1

Online

Online

Subject Contact Felix Ogbo Opens in new window

Attendance Requirements 80% attendance rate is imposed in all core subjects’ due to the nature of class activities that are aligned with subject assessments.

View timetable Opens in new window

Parramatta - Victoria Rd

Day

Subject Contact Felix Ogbo Opens in new window

Attendance Requirements 80% attendance rate is imposed in all core subjects’ due to the nature of class activities that are aligned with subject assessments.

View timetable Opens in new window