CHEM 3014 Pharmacological Chemistry
Credit Points 10
Legacy Code 300920
Coordinator Krishant Deo Opens in new window
Description This subject is aimed at undergraduates with grounding in chemistry and biochemistry who have an interest in a career related to medicinal chemistry. Because it concerns the manner in which foreign molecules can interact with the body's mechanisms it is of direct relevance not only to the pharmaceutical industry but also to the food, agricultural, cosmetic (etc) industries. It conveys the fascination of designing chemical structures for particular uses within biological systems and which overlap the disciplines of chemistry, biochemistry, cell biology and pharmacology. Emphasis is placed upon design of the chemical structure itself rather than an investigation of the specific chemical structure of its site of action in the body. This is reflected in the laboratory work which traces the historical development of drug design, essentially through a process of a series of inorganic syntheses, relevant to a range of common drugs.
Student Contribution Band HECS Band 2 10cp
Check your fees via the Fees page.
Level Undergraduate Level 3 subject
Equivalent Subjects LGYA 5935 - Pharmacological Chemistry
This subject is aimed at undergraduates with a grounding in chemistry and biochemistry.
- Obtain an understanding of the classification of drugs by chemical structure, by pharmacological effect, by target, and by site of action
- Identify the type of physicochemical and chemical forces that govern the interaction of a drug with its target
- Obtain an understanding of the stereochemical and conformational requirements of drug-target interactions
- Obtain an appreciation of the design of drug analogues based upon knowledge of targets and drug structure using quantitative structure-activity relationships (QSAR) methodologies
- Relate modern methods used to synthesise, purify and analyse drugs in the drug design process and demonstrate this by undertaking experiments which explore structure and biological response
- Synthesise, characterise, and measure the biological activity of a that compound
- Research and present lecture and written report on an assigned major group of drugs
- Record the results of and the outcomes of their laboratory investigations demonstrating awareness of the conventions of scientific writing and graphical presentations to produce a formatted manuscript
2. Peptide and Protein Structure
3. Nucleic acids
4. An Overview of the Major Drug Classes
6. Drug Action at Receptors
7. Introduction to Structure-Activity Relationships
8. Quantitative Structure-Activity Relationships (QSAR)
9. Student topic seminars on major group(s) of drugs: that may include Non Steroidal Anti-Inflammatory Agents, Steroidal Anti-Inflammatory Agents, Adrenocortical Steroids, Local Anaesthetics, General Anaesthetics, Androgens/Anabolic Steroids, Estrogens and Progestins, Cardiovascular Vasodilators, Hypoglycemic Agents, Anti-Depressants, Narcotic Analgesics, Hypnotics/Minor Tranquillizers, Antihistamines, Prostaglandins, Antimicrobial agents such as Penicillin, Tetracycline and Streptomycin, Anticoagulants, Antimalarial Agents, Anticancer Drugs, Antiviral agents, Radio Therapy
The following table summarises the standard assessment tasks for this subject. Please note this is a guide only. Assessment tasks are regularly updated, where there is a difference your Learning Guide takes precedence.
|Report||15 pages, in Times New Roman font, 12 point and 1.5 spaced (including figures and references)||45||N||Individual|
|Final Exam||over weekend||25||N||Individual|
- Benjamin, B 2015, Basic principles of drug discovery and development, Academic Press, London. https://westsydney- primo.hosted.exlibrisgroup.com/permalink/f/1vt0uuc/UWS-ALMA51165977780001571