Credit Points 10

Legacy Code 300906

Coordinator Christopher Gordon Opens in new window

Description This subject builds on the reactions learnt in the subject Organic Chemistry, extending the range of C-C bond forming reactions to include the most significant in modern synthesis. In the second stage students learn to develop multistep synthetic strategies to produce target molecules using their level 2 organic chemistry and the reactions above. Structural analysis by mass spectroscopy and more advanced NMR techniques is also investigated. The students use this chemistry in a lab course designed to highlight a number of these concepts (including the synthesis of 2 pharmaceutical compounds and a team experiment) and to extend their range of practical skills.

School Science

Discipline Organic Chemistry

Student Contribution Band HECS Band 2 10cp

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Level Undergraduate Level 3 subject

Pre-requisite(s) CHEM 2008

Equivalent Subjects LGYA 6141 - Drug Design and Synthesis CHEM 3013 - Organic Chemistry 3

Restrictions

Successful completion of 60 credit points

Learning Outcomes

On successful completion of this subject, students should be able to:

1. Apply relevant knowledge to major carbon-carbon bond forming reactions in organic chemistry
2. Analyse information on a range of chemical reactions and the reagents, solvent and conditions to predict the structure of reaction major product and by-products
3. Analyse and apply scientific knowledge to solve problems on the mechanism, regio- and stereo-specific organic reactions with experimental outcomes across the discipline
4. Explain reactions of simple heterocyclic systems
5. Analyse and interpret qualitatively and quantitatively the spectroscopic data (Infrared, UV and 1H,13C Nuclear Magnetic Resonance (NMR) spectroscopy and mass spectral data) to elucidate the organic molecular structures
6. Successfully plan and conduct basic chemical investigations on synthetic techniques for organic compounds carrying out the risk assessments and conforming to safe laboratory practices, either individually or a member of a team
7. Generate a formal Lab report and/or record of the experimental data, by interpreting data with an awareness of the conventions of scientific writing with chemical mechanisms, critiquing the methodology, accuracy and reliability of data and proposing strategies to improve

Subject Content

1. Nucleophilic C-C bond forming reactions
2. C-C bond formation via palladium coupling and ring closing metathesis
3. C-C bond formation via orbital symmetry controlled reactions
4. Introductory heterocyclic chemistry
5. Spectroscopy (IR, UV, Mass & 1H and 13C NMR)
6. Synthetic design
7. Total organic synthesis