The subject builds on fundamentals of pathophysiology and podiatry specific subjects to understand and manage the impact of systemic disease on foot health. The subject specifically investigates pathology associated with the 'high risk foot' including lower extremity manifestations associated with vascular, endocrine, neurological pathology and immunosuppression. This subject aims to develop comprehensive, coherent and connected knowledge to assist making informed decisions and contribute to sustainable change and improvements in health care for people with systemic disease, with particularly emphasis on diabetes and wound management.