On successful completion of this subject, students should be able to:

1. Describe the structure of the human genome and common genetic variants in the genome
2. Explain the mechanisms by which the integrity of the human genome is maintained and relate errors in these pathways to human health
3. Compare and contrast the genetic basis of rare single-gene Mendelian disorders with common complex multi-gene disorders
4. Describe methods of genetic analysis as applied to single gene and multi-gene disorders
5. Evaluate the role of genetics in exploring the relationship between lifestyle, the environment, and common human diseases
6. Gather information, plan, complete and analyse experiments in molecular genetics

1. Genomes and genetic variation: comparative analysis genomes; the human genome project; defining genetic variation; examining how genetic variation can identify individuals and populations
2. The origins of genetic variants in the human genome: mechanisms that maintain the integrity of the human genome; errors in DNA repair that are associated with disease
3. Epigenetics and health: X-inactivation and imprinting
4. Rare and common genetic variants: Mendelian and non-mendelian inheritance of disease; exploring the relationship between genotype and phenotype
5. Genetic analysis: single-gene and whole-genome approaches; designing a study to search for a genetic basis of disease
6. Genetic basis of common diseases: asthma; obesity; dementia; the effect of lifestyle and the environment
7. Cancer: heritable and non-heritable cancer; breast cancer and melanoma
8. Pharmacogenomics: correlating drug response to individual genotype; prediction of therapeutic response based upon individual genotype
9. Human ethics